Depending on the brand, the Sildenafil in Cenforce 200 tablet is used to address pulmonary arterial hypertension in both men and women (Revatio brand) or erectile dysfunction (ED or impotence) in men.
Sildenafil inhibits the activity of the cGMP-specific phosphodiesterase type-5 enzyme (PDE-5). This enzyme degrades the neurotransmitter cGMP, which causes smooth muscle relaxation. Increased cGMP levels in smooth muscles as a result of blocking PDE-5 encourage muscular relaxation and vasodilation (a widening of blood vessels).
The retina, lungs, and penis all contain high concentrations of PDE-5. PDE-5 is also present in the body’s smooth muscle cells, which are found in the blood vessels and muscles.
The group of drugs called as sensitive phosphodiesterase (PDE) type 5 inhibitors includes sildenafil.
Upsides
- After sexual excitement, sildenafil improves blood flow to the penis. It accomplishes this by inhibiting the enzyme that breaks down cGMP. cGMP is a chemical that relaxes and expands smooth muscle cells as well as blood vessels. Men can maintain a strong enough arousal for sex because of this.
- Sildenafil only functions after sexual stimulation. It takes between 30 and 60 minutes to start working, however it can be given up to four hours beforehand.
- Pulmonary arterial hypertension-related high blood pressure is decreased with sildenafil (PAH). This enhances exercise capacity in those with PAH and prevents any symptom exacerbation.
- For PAH, a preparation is available orally and intravenously. For ED, given orally.
- Sildenafil, a generic version of Revatio, is readily available (20mg tablet). In 25mg, 50mg, and 100mg dosages, sildenafil, a generic form of Viagra, is also offered.
Downsides
The following adverse effects are more likely to occur if you are between the ages of 18 and 60, do not take any other medications, or have any other medical conditions:
- The most frequently reported symptoms include dyspepsia, flushing, headache, digestion, muscle or back discomfort, and vision abnormalities.
- Insomnia, nasal congestion, a runny nose, or nosebleeds are a few additional side effects. Blood pressure drops are another. Additionally, reports of sudden hearing loss exist. Sildenafil users occasionally experience bleeding incidents, but it is unknown whether this is linked to sildenafil use.
- Rarely, a reduction in blood supply to the optic nerve may cause an unexpected loss of eyesight. People over 50, those with diabetes, heart disease, elevated blood pressure, high blood cholesterol, smokers, and those with specific pre-existing eye conditions are at higher risk.
- In rare cases, it may result in unpleasant erections that persist longer than 4 hours. Immediately consult a doctor if this occurs.
- Some patients, including those who suffer from angina, chest pain, or other cardiac ailments, liver or kidney issues, blood disorders, stomach ulcers, specific eye conditions, or a physical malformation of the penis (such Peyronie’s disease), may not be a good candidate.
- In children with PAH, greater sildenafil dosages are linked to an increased risk of death. The FDA does not advise use in children under the age of 18 because of this.
- Some treatments, such as some antibiotics and antifungals, herbal treatments, HIV meds, nitrates, and prescriptions for high blood pressure or prostate issues, may interact with one another. Other PDE-5 inhibitors shouldn’t be taken with sildenafil.
- If you have renal or liver issues, you might need to reduce your dosage.
- To determine whether sildenafil contributes to female sexual dysfunction, more investigation is required.
- There is no protection against STDs provided by sildenafil.
To Sum Up
Both pulmonary arterial hypertension and erectile dysfunction (ED) are treated with sildenafil to lower blood pressure (PAH). For ED as required and for PAH every day, it is taken. The biggest adverse effects include a headache, upset stomach, and flushing, and it shouldn’t be used within 24 hours of a nitrate.
Tips
Do not consume sildenafil more than once per day if you are treating ED with it. one hour before engaging in sexual activity (range 30 minutes to 4 hours). It can take longer for it to start working if you take it with a meal that is high in fat.
Take sildenafil as prescribed if you are taking it for PAH (the usual dosage is three times daily). You have the option of taking it with or without meals.
While taking sildenafil, avoid consuming grapefruit or grapefruit-related items.
Before using ANY medicine like Cenforce 200mg for ED, ALWAYS consult your doctor. Some ED drugs should not be used by guys.
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